The station was opened in 1912 by the Pennsylvania Railroad as part of a project to elevate the right-of-way as it passed through Greensburg.

[4] The depot is constructed of red brick laid in a Flemish bond pattern with stone trim and quoins on the building's corners; the overall architectural style is Jacobean Revival.

[5] From March to November 1981, the station was the eastern terminus of PennDOT's Parkway Limited train, which took commuters to Pittsburgh.

Until 2005, Greensburg was served by the Three Rivers (a replacement service for the Broadway Limited), an extended version of the Pennsylvanian that terminated in Chicago.

Its cancellation marked the first time in Greensburg's railway history that a single daily passenger train served the town.