Greenville was platted in 1816 by Andrew Mundell and Benjamin Haines some three years before Floyd County was established.

During the first three years of Greenville's development, the village was a part of Clark County.

[4] Captain John Baptiste Ford found his way to Greenville as a 14-year-old runaway from Danville, Kentucky.

Ford began as an apprentice with his future father-in-law in the local saddle shop which led him into his first business venture.

Ford purchased the Old Mill and saddle shop from its owner, added a grocery and began making tin pie safes which he sold throughout the country.

Later, Ford moved to New Albany and established several businesses, and became the first man to succeed in making plate glass in the United States.

[5] That original building that housed the mill, saddle shop and grocery still stands today.

The Station was a stop for the 104-mile stagecoach route that ran from Falls Cities to the Wabash River.

Ford was a philanthropist and always gave back to the community even after he left Greenville.

[11] Greenville resident Ephraim L. Girdner enlisted with the Union Army in 1861.

The contest was animated but New Albany added the donation of a bell for the court house.

[13] Greenville was surveyed by George Smith, county surveyor, and incorporated October 28, 1879.

Today, the Station stands just two doors from one of the city's oldest home (rebuilt in 1908), which still boasts some of John B. Ford's original plate glass works.

[16][17] The Simpson Memorial United Methodist Church was listed on the National Register of Historic Places in 2004.

[18] According to the 2010 census, Greenville has a total area of 0.78 square miles (2.02 km2), all land.

Big and Little Indian Creeks meander through the township, which are tributaries in the Ohio River watershed.