The combination passenger station and freight warehouse was designed by the Charlotte, North Carolina-based architect, Charles Christian Hook, and constructed in 1913 for the Piedmont and Northern Railway.

The depot was designed as a combination passenger station and freight warehouse for the Piedmont & Northern Railway and later used by Seaboard Coast Line Railroad, before facing potential demolition in 1983.

[3] The depot, which had been boarded up and unused from the early 1970s until 1983,[3] was saved from the wrecking ball by Greenville County Redevelopment Authority in 1984 before being sold to Station One Partnership in 1987.

[4] The building was sold to Western Carolina Railway Service Corporation (WCRS) subsidiary Letchworth Properties, LLC, in 2017.

The latter dedication was timed to coincide 108 years to the day of the first Piedmont and Northern passenger train departing Greer Depot on October 15, 1913.