[4][5][clarification needed] Berlanti also directed the 2018 film Love, Simon, a gay romantic comedy-drama which grossed $66 million worldwide.

[12] By the age of 32, he had also already directed his first feature film, The Broken Hearts Club: A Romantic Comedy,[13] which starred Timothy Olyphant, Zach Braff, Justin Theroux, and Dean Cain.

[15] In 2006, Berlanti produced and wrote Brothers & Sisters for ABC, which aired for five seasons and featured the first same-sex legal marriage on network television.

[17] In 2007, Berlanti executive-produced Dirty Sexy Money for ABC, which aired for two seasons and featured the first recurring transgender character on primetime television.

[18] In 2008, Berlanti created and produced the ABC legal drama Eli Stone[19] and, in 2012, the USA miniseries Political Animals.

[20] At ABC, he produced and worked alongside Jon Harmon Feldman, former Dirty Sexy Money showrunner, to create No Ordinary Family.

[25] In January 2016, The CW ordered the Berlanti-produced television pilot Riverdale, based on the characters from Archie Comics.

[32][33] In February 2015, it was announced that Berlanti and Sera Gamble would develop a series for Showtime based on Caroline Kepnes's thriller novel You.

[45] In April 2019, Amazon Studios officially won the film rights to Red, White & Royal Blue, to be produced by Berlanti Productions.

[46] The project, based on the 2019 novel of the same name by Casey McQuiston, had its world premiere at the BFI IMAX in London on July 22, 2023[47] and was released on Amazon Prime Video on August 11, 2023.

[48] In May 2021, The CW pilot All American: Homecoming was picked up to series to be executive produced by Berlanti in association with creator Nkechi Okoro Carroll, Sarah Schechter, David Madden, and Robbie Rogers.

[51] In February 2022, Max put in a series order for The Girls on the Bus, previously worked on by Netflix and The CW, to be produced by Berlanti, Amy Chozick, Julie Plec, Rina Mimoun, and Sarah Schechter.

[54] Berlanti co-wrote and co-produced the DC Comics film Green Lantern, starring Ryan Reynolds as the titular character.

[55] In May 2016, Berlanti discussed his involvement, as producer and possibly as director, in a Booster Gold feature film that was in development.

[59] On July 30, 2013, it was announced at the summer TCA tour that Berlanti, Kreisberg, and DC Comics CCO Geoff Johns would be introducing Barry Allen in the second season of Arrow, with the possibility of the character being spun off to his own series.

In November 2013, The CW officially ordered a pilot for The Flash,[60] and in May 2014, the network picked the project up to series, with a premiere scheduled for autumn of that year.

[61] On February 26, 2015, it was announced that Berlanti, along with Guggenheim and Kreisberg, would write and executive produce a spin-off series featuring The Atom (Brandon Routh), Captain Cold (Wentworth Miller), Martin Stein (Victor Garber), and The White Canary (Caity Lotz), for a potential 2016 premiere.

[62] The series was ultimately titled Legends of Tomorrow, and it followed a ragtag team of heroes and villains as they traveled through time and space on a mission to stop the devious immortal Vandal Savage.

[63] On September 4, 2014, it was reported that Berlanti would executive-produce a re-imagining of the origin of Supergirl, to be written by The New Normal and Chuck alum Ali Adler.

[72] In 2019, it was announced that Berlanti would be producing shows based on Green Lantern and Strange Adventures for HBO Max.

[76] He described his early life in an August 2004 interview with Entertainment Weekly: "We were Italians in a town of WASPs" and his family was not "doing as well as 90% of the community.

Additional honors include: Los Angeles LGBT Center's 49th Anniversary Gala Vanguard Awards Honoree;[90] Friends of the Saban Community Clinic's 43rd Annual Gala Honoree;[91] Variety Hall of Fame Inductee;[92] Northwestern University School of Communication Graduation Convocation Address.

Berlanti said he "aims to help Northwestern continue its great legacy of fostering the next generation of humane, diverse, courageous and bold storytellers.

[110] Berlanti said that his mother Barbara was the most charitable person he ever knew and that there was no better way to honor her than a night of fun and giving back to this incredible organization.