Dulli is known as the voice of John Lennon in the 1994 film Backbeat, and has produced music for musicians such as Afterhours,[2] and is known as a regular collaborator of Mark Lanegan and Joseph Arthur.

[6] In 1983, he studied film at the University of Cincinnati, but later dropped out after a year and a half, moving to Los Angeles and working at Tower Records on Sunset Boulevard while attempting to become an actor.

[8] In 1994, Dulli was featured in Backbeat, a film detailing the pre-fame years of the Beatles, where he portrayed John Lennon's singing voice.

Dulli and Mark Lanegan formed a group named the Gutter Twins, and signed to Sub Pop in 2008, releasing their debut album Saturnalia on the label,[24][25] as well as an extended play Adorata in the same year.

[27] Later that year, Dulli released a solo live album, featuring content he had recorded at The Triple Door in Seattle, for the A Drink for the Kids fundraising effort by The Vera Project.

[29] In October 2010, for the first time in his career Greg Dulli embarked on a solo tour, which saw him perform twenty-nine shows in five different countries.

[25] After the release of In Spades and the death of Afghan Whigs' guitarist Dave Rosser, Dulli began to work on his first solo album.

Dulli co-owns three bars in Los Angeles: Short Stop on Sunset Boulevard (which he purchased in 2001), Club Tee Gee in Atwater Village[20][37] and Footsies in Cypress Park.