He is the incoming head coach and director of football for Major League Soccer club Chicago Fire, a role he will assume following the end of the 2024 season.

He originally served in the role from 2018 to 2022; following the expiration of his contract, U.S. Soccer employed interim head coaches before rehiring him to the post on June 16, 2023.

[11] In his first season with the Galaxy, their goals against were cut in half—from 61 to 30—with Berhalter being a leader in defense while mentoring Omar Gonzalez to Rookie of the Year honors.

On November 14, 2009, he scored in the 103rd minute of the scoreless Western Conference final, propelling the Galaxy to a 2–0 win over the Houston Dynamo and into the 2009 MLS Cup.

[15][16] On May 25, 2006, Berhalter was added to the U.S. national team's roster for the 2006 World Cup, replacing the injured Cory Gibbs.

On November 12, 2021, Berhalter led the United States to a 2–0 victory over rival Mexico in World Cup Qualifying at TQL Stadium in Cincinnati, Ohio.

[27] As coach of the USMNT, Berhalter has built a roster of young players including Christian Pulisic, Tyler Adams, Yunus Musah, Folarin Balogun, Sergiño Dest, Antonee Robinson and Weston McKennie.

[28] Sportswriters such as Sports Illustrated's Brian Straus, The Guardian's Nancy Armour and The Athletic's Paul Tenorio have described this as part of an overarching strategy to develop a pool of young soccer talent in the United States in preparation for the 2026 FIFA World Cup.

[25][28] Berhalter's contract expired on December 31, 2022, with assistant Anthony Hudson named interim head coach while a search for a permanent replacement commenced.

[34] On June 16, 2023, U.S. Soccer announced that Berhalter would return as the head coach of the United States through the 2026 FIFA World Cup.

[35] Sporting director Matt Crocker cited Berhalter's "vision, as well as the experience and growth mindset on and off the field to move [the] team forward" as the U.S. prepares to host the 2026 World Cup with Mexico and Canada.

[36] On July 10, 2024, Berhalter was relieved of his duties as the US men's national team head coach after the early exit in the 2024 Copa America group stage.

[37] On October 8, 2024, Berhalter was named head coach and director of football for MLS club Chicago Fire FC starting from the 2025 season.

[42] In March 2023, an investigation by the United States Soccer Federation (USSF) found that Claudio Reyna and his wife Danielle had attempted to retaliate against Berhalter because their son Giovanni was receiving limited playing time at the 2022 World Cup.