Gregorio de Salinas Varona (1647 or 1650 in Tormé, Burgos, Spain – 1720 in Mexico City, New Spain, Spanish Empire) was a noble and Spanish administrator who served as governor in Texas, Coahuila, Nuevo Leon (the latter two localized in Mexico), Honduras and Pensacola.
Soon after his arrival in New Spain, he was sent to the Gulf of Tehuantepec to lead Spanish forces against pirates and smugglers in the region.
The expedition also constituted the escorting of four Franciscan friars to found their first mission in Texas called San Francisco de los Tejas.
Later in the same year, he was sent to accompany an expedition run by Domingo Terán de los Ríos to extend Spanish missions into Eastern Texas.
During his tenure in Coahuila, he extended the scope and presence of missions and concentrated on colonizing the local Indians.