Gregory-Portland High School is a 5A secondary school in Portland, Texas and is a part of the Gregory-Portland Independent School District in southeastern San Patricio County.

In addition to Portland, the school also serves the city of Gregory as well as the census-designated place of Tradewinds.

[3] The new Gregory-Portland High School was completed in the fall of 2002.

The current High School is large enough (in size) to be a 6A school, capable of a student capacity of 2,400.

Gregory-Portland has been noted as a: