He is located in the tradition of the early American Modernist painters Georgia O'Keeffe, Charles Burchfield, Milton Avery, Arthur Dove and Marsden Hartley.
In the early 80s his work was often associated with a style of painting called organic abstraction and exhibited alongside artists Bill Jensen, Katherine Porter and Terry Winters.
A retrospective of works on paper originating at the DeCordova Museum and Sculpture Park in Lincoln, Massachusetts, titled Gregory Amenoff, Works on Paper 1975–1992 traveled to Massachusetts, Tampa Museum of Art, Tampa, Florida, Norton Gallery of Art, West Palm Beach, Florida, Wellington Gray Gallery, and East Carolina University, in Greenville, North Carolina.
Amenoff was also the subject of a two-year traveling show of small paintings Thirty Views, which originated in Syracuse, New York and went to venues in Boston, San Francisco, and elsewhere.
He has taught at Columbia University since 1994, where he holds the endowed Chair as the Eve and Herman Gelman Professor of the Visual Arts Program.