The Greiner–Murray ministry (1988–1991) or First Greiner–Murray ministry or First Greiner ministry was the 80th ministry of the New South Wales Government, and was led by the 37th Premier of New South Wales, Nick Greiner, representing the Liberal Party in coalition with the National Party, led by Wal Murray.

The ministry covers the period from 21 March 1988 when the coalition defeated the sitting Unsworth Labor government at the 1988 state election until 6 June 1991, when Greiner reconfigured his ministry following victory at the 1991 state election.

The ministry was rearranged on four occasions.

Ministers are members of the Legislative Assembly unless otherwise noted.