The southern side is populated mainly by office buildings, including the Grenfell Centre ("the Black Stump") at no.

At the eastern end of Grenfell, a dedicated bus track carries buses across East Terrace into the O-Bahn tunnel under Rymill Park.

102a Grenfell, was built by a Mrs Phillipson, of Glenelg, for the use of the Adelaide German Club (Allgemeiner Deutscher Verein) in 1894, opening in June of that year.

Its use turned to performances, mainly concerts, operas, dramas, and fundraisers for World War I, and it also hosted occasional variety shows.

The building was partially destroyed by fire on 4 November 1929, and it fell into disuse until it was refurbished and reopened in 1933 as the Embassy Ballroom, which had an Art Deco facade.

A "Historic Engineering Plaque" is located on a ground level plinth just east of the north-east corner of the Tandanya building, which was dedicated by the Institution of Engineers, Australia, the Electricity Trust of South Australia and the Adelaide City Council on 6 April 1995.