Grey—Simcoe was a federal electoral district represented in the House of Commons of Canada from 1968 to 1988.

It initially consisted of the City of Owen Sound, the Village of Chatsworth and the Townships of Collingwood, Euphrasia, Holland, Osprey, St. Vincent, and Sydenham in the County of Grey; and Christian Islands Indian reserve No.

30 and the Townships of Flos, Nottawasaga, Sunnidale and Tiny (excepting the Town of Penetanguishene) in the County of Simcoe.

In 1976, it was redefined to consist of the City of Owen Sound, the Townships of Artemesia, Collingwood, Euphrasia, Proton, Osprey, Sarawak, St. Vincent, and Sydenham (including the Town of Markdale) in the County of Grey; and the Townships of Nottawasaga and Sunnidale (including the Town of Wasaga Beach) in the County of Simcoe.

This riding has elected the following members of Parliament: