The hospital suffered a major fire in 1765 and was rebuilt again according to the style of French architecture, that is to say, with large walls composed of rough stone called rubble that had been squared and covered in plaster.

The structure, being less massive and simpler to build meant a lower risk of fire.

Finally, wrought-iron esses are used to reinforce the structure with stems screwed into the wood frame.

On the original site, the eastern wings and most of the central chapel were demolished to make way for an extension of Saint-Pierre Street and the construction of new rental shop-warehouses, while the remaining half of the old building was also rented as warehouses.

The rental income from the old site thus helped support the continued charitable work at the new location.