Griffin is a town in Bethel Township, Posey County, in the U.S. state of Indiana.

[4] The present name honors Samuel Griffin, an early postmaster.

[6] The town was destroyed by the 1925 Tri-State tornado on the afternoon of March 18, 1925, killing 44 people and injuring over 200.

In 1972, a nearby outdoor rock concert Erie Canal Soda Pop Festival caused quite a stir in the town over the course of three days.

[7] According to the 2010 census, Griffin has a total area of 0.07 square miles (0.18 km2), all land.

The racial makeup of the town was 98.8% White, 0.6% African American, and 0.6% from two or more races.

About 7.0% of families and 17.9% of the population were below the poverty line, including 40.7% of those under the age of eighteen and 22.2% of those 65 or over.