It is an industrial town with AB Grigiškės, a major paper factory built in 1923.

Mounds from the 5th to 10th centuries show that the surrounding lands have been inhabited for a long time.

Kunigiškės, Kauno Vokė and Salos-Afindevičiai villages were there, with the modern Grigiškės settlement being founded only in the 20th century.

The town grew rapidly mainly due to the migration of Belarusian workers from Byelorussian Soviet Socialist Republic as well as Lithuanian deportees returning from Siberia, who were prohibited to live in Vilnius, settled here.

On 10 December 1996, by the decree of the Lithuanian president, the Grigiškės coat-of-arms was finally validated.