Groß-Enzersdorf is a town and municipality in the district of Gänserndorf in the Austrian state of Lower Austria, directly east of Vienna and north of the river Danube.

The area comprising this estate (the island Sahsonaganc, which roughly coincides with today's municipality) was donated to the Weihenstephan Abbey by Henry II in 1021, only to be transferred to the Diocese of Freising in 1028.

During the Thirty Years' War in the first half of the seventeenth century, the town was occupied and again set on fire by troops of the Swedish Empire.

In 1693, Georg Rafael Donner, a baroque sculptor, who was born in the neighboring village Eßling, was baptized in Groß-Enzersdorf, marking the beginning of a relatively calm period, interrupted only by another major fire in 1730.

From 1886 , the town was the terminus of a steam tramway connecting to the Viennese tram network, which was later electrified, however it ended its service in 1970.

During the Second World War, the town suffered aerial bombings by the Allied Forces due to its vicinity to an oil refinery in the Lobau.

The more recent history of Groß-Enzersdorf marks a shift from a service town characterized by its agricultural surroundings towards a suburban center, with many inhabitants commuting to Vienna.

The town cointains the Marchfeld Center, a strip mall containing multiple different chainstores, including a grocery, a shoe store, a pet supply sore and an opticians.