Groß Gerau station is located approximately 500 metres north of the centre of the town of Groß-Gerau in the German state of Hesse on the Rhine-Main Railway, running from Wiesbaden and Mainz to Darmstadt and Aschaffenburg.

[5] During the First World War, a volunteer ambulance corps and a branch of the Red Cross run by the ladies of the Alice-Hospital (founded by Princess Alice, Queen Victoria’s daughter) operated in the station building.

The station building is now recognised as an historic landmark under the Hessian Heritage Act.

To the west there is a connection to a former site of the sugar manufacturer Südzucker, which operated an extensive system of tracks.

[8] The station is served by the Regionalbahn service RB 75, running every hour (during peak hours every 30 minutes) from Wiesbaden via Mainz to Groß Gerau and continuing through Darmstadt to Aschaffenburg.