Großhennersdorf (Upper Sorbian: Wjelikohennersdorf) is a village and a former municipality in Görlitz district, Saxony, Germany.

The town is best known perhaps as the home of Henriette Catharina von Gersdorff m.n.

She raised her grandson, Nicolaus Ludwig, Imperial Count von Zinzendorf und Pottendorf (1700–1760), the Renewer of the Unitas Fratrum i.e. Moravian Church, in the Castle (now in ruins) in Großhennersdorf.

She was an extremely talented, well educated woman, conversant in several languages, an author and poet, with connections all over Europe.

The municipality subdivisions include Großhennersdorf, Neundorf, Schönbrunn, Euldorf and Heuscheune.