[9][10] Elementary schools feeding into GPSHS include all of the zones of Defer, Kerby, Maire, Père Gabriel Richard, and Trombly.

[15] Grosse Pointe High School hosted game 1 of the NBA's Western Divisional Semi-finals vs the Detroit Pistons and Minneapolis Lakers on March 12, 1960.

These sports include baseball, basketball, competitive cheer, crew, cross country, field hockey, figure skating, football, golf, gymnastics, ice hockey, lacrosse, sailing, soccer, softball, swimming and diving, synchronized swimming, tennis, track and field, volleyball, and wrestling.

Grosse Pointe South competes in the Macomb Area Conference (MAC), under the regulation of the Michigan High School Athletic Association (MHSAA).

The team fundraised, designed, built, and raced their street-legal car on Texas Motor Speedway followed by a road test challenge.