[3] All growth factor receptors are membrane bound and composed of 3 general protein domains: extracellular, transmembrane, and cytoplasmic.
[6] These phosphorylations allow for other intracellular proteins to bind to with the phosphotyrosine-binding domain which results in a series of physiological responses within the cell.
[6] Research in today’s society focus on growth factor receptors in order to pinpoint cancer treatment.
Epidermal growth factor receptors are involved heavily with oncogene activity.
[7] Furthermore, in certain cancers, receptors (such as RTKs) are often observed to be overexpressed, which corresponds to the uncontrolled proliferation and differentiation of cells.