Grupo Banistmo was a Panamanian financial services company, and the largest in Central America.

In 1999 it began an expansion strategy that has resulted in the acquisition of banks in several Central American countries, as well as Colombia and the Bahamas.

It was the holding company of Primer Banco del Istmo, S.A. or Banistmo, the largest bank in Panama.

Its President and Chief Executive Officer was Alberto Vallarino.

In 2013 Bancolombia Group acquired HSBC Panama and renamed it Banistmo.