Upon finishing his degree, he worked as a lecturer in Contemporary Spanish Literature at Lebanon Valley College in Pennsylvania, living in the United States during the decisive year of the Watergate case.

This incident led to a historic resolution issued by the Constitutional Court, dismissing the decision by the Military Justice and proclaiming readers' rights to information for the first time since the establishment of democracy.

On 8 March 1989 he was dismissed as director of Diario 16 because of disagreements with the editor of the newspaper about the allegedly sensationalist tone of reports concerning the GAL (Anti-terrorist Liberation Groups).

On 23 October 1989, seven months after his dismissal, he founded the newspaper El Mundo, along with three high-ranking executives from Grupo 16: Alfonso de Salas, Balbino Fraga and Juan González.

On the eve of the Azores summit, Pedro J. Ramírez published one of his routine Sunday letters, titled 'One Hundred Reasons against the Invasion of Iraq.'

From the editorial perspective, it has opposed negotiations with ETA and the new Catalan Statute, which led to votes cast for the Partido Popular and the small party headed by Rosa Díez during the general elections held on 9 March 2008.

After being ousted as editor he contributed a series of Sunday letters to the newspaper for a few months,[4] before turning his attention to setting up a news website El Español, which went online in 2015.

[5][6] Following a criminal investigation, the Madrid Court convicted the former personal aide of Felipe González at the Moncloa, Ángel Patón; the former civil governor of Guipúzcoa, José Ramón Goñi Tirapu; and four others, of violation of the right to privacy, sentencing them from two to four years in prison.

In 2007, Unedisa, the publishing company of El Mundo -already widely controlled by the RCS group, owner of Corriere della Sera- acquired 100% of the shares in Grupo Recoletos, a leader in specialised press in Spain.

As a result of this operation, Pedro J. Ramírez, as General Editorial Director, was put in charge of content published in newspapers such as Marca, Expansión and Diario Médico; magazines including Telva and Actualidad Económica, and the television channel Televisión Digital Veo TV.