Most of the district's territory lies on the Gryazovets Plateau, which is cut through by rivers and is of glacial origin.

[11] In the course of the administrative reform carried out in 1708 by Peter the Great, the area was included into Archangelgorod Governorate.

The viceroyalty was abolished in 1796, and its part which included Gryazovetsky Uyezd became Vologda Governorate.

Instead, Gryazovetsky District with the administrative center in the town of Gryazovets was established as a part of Vologda Okrug.

The agriculture of the district is essentially limited to crop growing and cattle breeding, resulting and meat and milk production.

[13] One of the principal highways in Russia, M8, which connects Moscow and Arkhangelsk, crosses the district from south to north, passing Gryazovets.

The railroad connecting Yaroslavl and Vologda crosses the district from south to north.

There is also another line, which connects Vologda in the north and Buy in the south, with the main station within the district being Vokhtoga.

[14] The district contains four objects classified as cultural and historical heritage by Russian Federal law and additionally ninety objects classified as cultural and historical heritage of local importance (fifty of them in Gryazovets).

[15] The objects protected at the federal level are the Intercession Church and the Bryanchaninov Estate, both located in the selo of Pokrovskoye, and the building of the secondary school in Gryazovets.