Guémené-Penfao (French pronunciation: [ɡemne pɛ̃fo] ⓘ; Gallo: Gemenae, Breton: Gwenvenez-Penfaou) is a commune in the Loire-Atlantique department in western France, north of Nantes.

The commune is widespread and includes the former communes of Beslé-sur-Vilaine and Guénouvry.

Its name comes from the Breton language: "gwen" (white), "menez" (hill, mountain), "pen" (head), and "faou" (beech tree).

The main economic activity is agriculture.

This Loire-Atlantique geographical article is a stub.