Guzmán made her professional debut on 7 July 2012, scoring a four-round unanimous decision (UD) over Maria Munos at the Palenque de la Feria in Chilpancingo, Mexico.
[4] Her next fight was against Ana Arrazola (17–9–2, 13 KOs) for the vacant WBF female light flyweight title against on 17 August at the Hotel Paraiso Caxcan in Apozol, Mexico.
[6] For her next fight she moved down in weight to challenge IBF female junior flyweight champion Naoko Shibata (11–3, 3 KOs) on 3 March 2014 at the Korakuen Hall in Tokyo, Japan.
[7] She won her next fight by split decision (SD) before making a second attempt at the WBA interim female super flyweight title, this time against Linda Laura Lecca on 30 August at the Complejo Deportivo "El Cancherín" in Huarochirí, Peru.
[12] Guzmán bounced back with two UD wins before facing WBC female super flyweight champion Zulina Muñoz (48–1–2, 28 KOs) on 13 May 2017 at the Grand Oasis Arena in Cancún, Mexico.