Guadalupe Tagliaferri (born 26 June 1974) is an Argentine politician, currently serving as a National Senator for the Autonomous City of Buenos Aires since 2019.

She previously served as Minister of Human Development of Buenos Aires in the administration of Chief of Government Horacio Rodríguez Larreta from 2015 to 2019.

[3][4] As minister, Tagliaferri oversaw the demolition of the Elefante Blanco, an abandoned hospital in the city's Villa Lugano barrio, and its replacement with a new building for the Ministry of Human Development.

[5][6] Ahead of the 2019 legislative election, Tagliaferri was internally selected to be the second candidate in the Juntos por el Cambio list to the Argentine Senate, after Martín Lousteau.

[9] Tagliaferri is one of the Senate's supporters of the Voluntary Interruption of Pregnancy Bill brought forward by President Alberto Fernández in 2020.