Guadalceo won two consecutive regional tournaments in 2011 and 2012, but again failed to achieve promotion in the national division.

After only playing in the regional division in 2013, the club again reached the Segunda Categoría in 2014, where they achieved promotion to the Serie B as champions.

After another seventh place in 2017, the club finished eleventh in 2018, but did not suffer relegation after the number of teams in the first division increased and the relegation in both first and second divisions were declared void.

After a third and sixth position finish in 2019 and 2020, respectively, Guadalceo achieved a first-ever promotion to the Serie A on 13 October 2021, after a 1–0 home win over Atlético Santo Domingo and El Nacional's draw with Independiente Juniors.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.