The Guamá River is located in northeast Pará state in north-central Brazil.

Its mouth forms the southern border of the state capital, Belém.

The navigability is feasible in the last 160 km (100 mi) of the river, from the municipality of São Miguel do Guamá to Guajará Bay.

The main campus of the Federal University of Pará, near Belém, is located on its right bank.

About 75% of the water consumed in Belém comes from this river, which receives 11 streams contaminated by the irregular disposal of urban waste, since only 4, 5% of the home network of the Pará capital is connected to the collecting network.