Despite being considered part of Oceania, and having never faced an Asian team to that point, Guam became an associate member of the AFC in 1991 but continued to participate in the Pacific Games.

In the 2005 East Asian Football Championship qualifiers, Guam lost all four matches heavily, against Chinese Taipei (9–0), Hong Kong (15–0), Mongolia (4–1), and North Korea (21–0).

Guam advanced to the second stage of qualifying in the 2008 East Asian Football Championship by beating Northern Marianas 12–2 over two legs but they were eliminated in the next round by Chinese Taipei (10–0), and Hong Kong (15–1).

Guam returned to the 2011 Pacific Games after a sixteen-year absence, but only managed to beat American Samoa 2–0, finishing second last and failing to advance to the knock-out stages.

Gary White became Guam's manager in 2012 and called-up players of Guamanian origin based in the United States like Ryan Guy and A. J. DeLaGarza to improve the level of his team.

During the 2022 World Cup qualifiers, Guam beat Bhutan 5–1 over two legs but lost all eight of their second round matches and finished bottom of their group, scoring two goals and conceding 32.

After nearly not playing an international match for a year, Guam participated in the first round of the 2026 FIFA World Cup qualification against Singapore, where they would ultimately lose 3–1 on aggregate.

INJ Withdrew due to injury PRE Preliminary squad RET Retired from the national team SUS Serving suspension