The Guará Area of Relevant Ecological Interest (Portuguese: Área de Relevante Interesse Ecológico do Guará) is an area of relevant ecological interest in the state of São Paulo, Brazil.

The Guará Area of Relevant Ecological Interest (ARIE) is divided between the municipalities of Iguape ( 44.89%) and Ilha Comprida (55.11%) in the state of São Paulo.

[3] The Guará Area of Relevant Ecological Interest was created by decree 53527 of 8 October 2008, which also created the Litoral Sul Marine Environmental Protection Area.

[5] A company was hired in 2013 to prepare a management plan for São Paulo's three marine environmental protection areas (south, center and north) and the ARIE, but the work was not completed.

In August 2016 a fresh start on a management plan was made by the Ekos Institute.