Guarani das Missões is a municipality in the state of Rio Grande do Sul, Brazil.

Guarani das Missões began as a Jesuit reduction settlement east of the Uruguay River.

In 1891 the federal government and colonial commission of Brazil assessed and divided the land for colonization.

The colony on the banks of the Uruguay would become the modern municipality of Porto Lucena whereas the land close to the Comandaí would be foundation for Guarani das Missões.

Revolutions in Brazil between 1894 and 1897 had caused a delay in the colonization of the region, with just an estimated 1,200 inhabitants between the Uruguay and Comandaí colonies.