Guarani belongs to the Vão do Paranã statistical microregion.

There are municipal boundaries with São Domingos, Iaciara, Posse, and the state of Bahia Guarani is located south of the Terra Ronca state park and 28 kilometers north of Posse.

Guarani is crossed by the Frei River, which has one of the most beautiful waterfalls in the region.

Connections are made by taking BR-153 / Anápolis / GO-060 / Alexânia / Planaltina / Formosa / GO-020 / BR-030 / Vila Boa / Alvorada do Norte / GO-108 / Posse.

In 1963 it was dismembered from São Domingos and formed a new municipality with the name Guarani de Goiás.