Guarene is a comune (municipality) in the Province of Cuneo in the Italian region Piedmont, located in the area of Roero about 45 kilometres (28 mi) southeast of Turin and about 50 kilometres (31 mi) northeast of Cuneo.

It is one of I Borghi più belli d'Italia ("The most beautiful villages of Italy").

The hilly parts of the commune are planted with vines and fruit trees.

The principle grape varieties are Arneis, Nebbiolo, Dolcetto and Barbera.

Towards the Tanaro, in Frazione Vaccheria the crops include tomatoes, peppers, garlic and cardoons.