This was the nation's seventh time competing in the Summer Paralympic Games since it made its debut forty years prior in Toronto, Canada.

Middle-distance runner Óscar Raxón Siquiej was the only athlete that Guatemala sent to Rio de Janeiro after he was awarded a wild card spot by the International Paralympic Committee.

[3] Middle-distance runner Óscar Raxón Siquiej was the only athlete to represent Guatemala at the Rio de Janeiro Summer Paralympic Games,[4] and was selected to be the flag bearer for the parade of nations during the opening ceremony.

[5] He was accompanied by the chef de mission of the team Noé Hinestroza, Siquiej's coach Luis Álvarez, doctor Erika Pérez and Paralympic attaché Rodolfo Quezada.

"[4] On 11 September, the heats of the men's 1500 metres T11 were held at the Maracanã Stadium, where the top six athletes would proceed to the final two days later.