It is the capital of the Guayaramerín Municipality in the Vaca Díez Province.

Guayaramerín is located on the west side of the Mamoré River, facing the Brazilian city of Guajará-Mirim.

Guayaramerín Airport is south of the city, and served by Ecojet.

Facing the city there is the small island of Suárez, or Guajará-Mirim as it is called by the Brazilian government.

The island is disputed by both countries, and treaties in 1867, 1877 and 1958 have failed to clear the matter.