Guayrá (initially called Gobernación del Guayrá) was a historical region of the Spanish Empire, located in the Governorate of Paraguay,[citation needed] within the colonial Viceroyalty of Peru.
It was located on the left bank of the Paraná, between the Iguazu and Pipiri-Guazu, which according to some sources was about 50 kilometres (31 miles) north of Salto del Guairá, in the territory of the cacique Canendiyu.
Guayrá was covered with dense forest and many rivers, and by 1600, it had become a place of refuge for the Guarani from the encomenderos of Paraguay and the Bandeirantes or esclavistas of Brazil.
In 1542, Alvar Nunez Cabeza de Vaca travelled through its southern reaches on his way to Asunción from Santa Catarina Island.
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