The Guggenheim Hermitage, designed by architect Rem Koolhaas, included 7,660 sq ft (712 m2) of space.

The museum was host to 10 exhibitions during its operation, featuring the work of leading artists such as Vincent van Gogh, Pablo Picasso, and Claude Monet.

[15] Its location on the Las Vegas Strip made it undesirable among locals,[16][17] with tourists making up approximately 95 percent of attendees.

[20] It eventually closed on May 11, 2008, having received approximately 1.1 million visitors throughout its history, with attendance declining in the final two years.

Among the artists represented were Claude Monet, Franz Marc, Pablo Picasso, Pierre-Auguste Renoir, and Vincent van Gogh.

[28][29][30] Later that year, the Guggenheim Hermitage hosted an exhibition of 16th and 17th century Russian items on loan from the Kremlin Museum.

[30][31] In 2006, the museum hosted an exhibition featuring the work of Peter Paul Rubens, as well as his pupils Anthony van Dyck and Jacob Jordaens.