He was a fan favourite at the Estadio Ciudad de La Plata, having graduated through the youth academy and making his first-team debut in 2011.

[citation needed] In February 2015, Estudiantes beat Barcelona Guayaquil 2–0 in their Libertadores Cup opener, played at La Plata “Único” stadium.

[8] On 25 January 2018, Carrillo joined Premier League side Southampton for a fee reported to be in the region of £19 million on a three-and-a-half-year deal.

[13] On 5 October 2020, Carrillo joined Spanish side Elche CF on a free transfer after an agreement was reached to terminate his contract with Southampton where he made just ten appearances for the club.

[14] On 30 August 2022, Carrillo completed a move to Chinese Super League club Henan Songshan Longmen on a free transfer.