He probably belonged to the family of the counts of Caprona, and was promoted to the College of Cardinals and appointed to the deaconry of Santi Cosma e Damiano by Pope Innocent II on 4 March 1132.
[2] He was widely travelled, intervening in Spain, Portugal, France and Germany, and well-connected, to Wibald, to Anselm of Havelberg and to a succession of popes as well as several emperors and kings.
[2][4] In June 1139 Guido was again in France as legate, holding a council at Uzès, where he resolved a dispute between the church of Lyons and the abbey of Cluny about which know nothing, and also revised his decision on the matter Bessan, forcing Saint-Thibéry to make an annual payment to La Chaise-Dieu as compensation.
[3] Guido returned to Rome by mid-November 1139, and he was still there in 1141, when the Papal curia deposed in absentia Abbot Ariulf of Saint-Riquier from the monastery of Oudenburg.
The Gesta Adalberonis records that he was "a very wise man and notably eloquent" (virum prudentissimum et breviloquio notabilem) and Otto of Freising singles him out: "many great and learned men [come] out of the Roman part of the Church, one of whom was Guido the Pisan, who was a cardinal and chancellor of [the Roman] court" (ex parte Romanae ecclesiae viros magnos et claros, quorum unus Guido Pisanus, eiusdem curiae cardinalis et cancellarius erat).