Guignard Brick Works is a historic industrial site and national historic district located in Cayce, Lexington County, South Carolina.

The brick works was established by the Guignard family in 1801 and over the years produced brick for many buildings in Columbia, South Carolina and throughout the South.

Clay for brickmaking was obtained from banks of the nearby Congaree River.

[2] The site was added to the National Register of Historic Places in 1995.

This article about a property in Lexington County, South Carolina on the National Register of Historic Places is a stub.