Guilá Naquitz Cave in Oaxaca, Mexico, is the site of early domestication of several food crops, including teosinte (an ancestor of maize),[1] squash from the genus Cucurbita, bottle gourds (Lagenaria siceraria), and beans.

[10] While the earliest human evidence in Guilá Naquitz Cave dates to about 10,750 years BP, inhabitation was not continual and was not year-long.

[8] Further excavations at the Guilá Naquitz site were carried out in the 1970s by a team led by Kent V. Flannery from the University of Michigan.

By circa 8,000 years BP the C. pepo peduncles found are consistently more than 10 mm (0.39 in) thick.

[4] The process to develop the agricultural knowledge of crop domestication took place over 5,000–6,500 years in Mesoamerica.