Guilford is a town in Piscataquis County, Maine, United States.

On October 8, 1812, a warrant was issued for the tract to be designated a "plantation," which became effective on November 11, 1806.

The town was officially incorporated by the governor of the Commonwealth of Massachusetts on February 8, 1816.

It was named after Moses Guilford Low, the first white child born here.

His visit drew large crowds to the Piscataquis County town.

33.5% of all households were made up of individuals, and 16.2% had someone living alone who was 65 years of age or older.

26.7% of all households were made up of individuals, and 14.0% had someone living alone who was 65 years of age or older.

[8] Guilford is an important setting in the science fiction novels Supervolcano Trilogy by Harry Turtledove.