Guilherme Afonso (born 15 November 1985) is a professional footballer who plays as a striker for Mendrisio-Stabio.

[1][2] Afonso has played club-football in Switzerland for Étoile Carouge, Sion, Grasshopper, Lugano and FC Vaduz; in France for Valence; and in the Netherlands for Twente and Veendam.

[3][4][5] In 2009 he scored the winning goal as Sion defeated BSC Young Boys 3–2 in the Swiss Cup Final.

[7] In the summer of 2013 he signed a year and half contract with Primeiro de Agosto.

[9] Afonso, who has previously played for Switzerland at under-21 level, was selected by Angola for the 2013 Africa Cup of Nations.