Born in São Paulo, Arana was a part of Corinthians youth squads for many years, being considered one of the top prospects of the club.

Arana was promoted to Corinthians' main squad after the 2014 Copa São Paulo de Futebol Júnior final and was an unused substitute in twelve matches of the 2014 Campeonato Brasileiro Série A.

[8] On 7 December 2017, Arana transferred to Spanish club Sevilla on a deal worth 12 million euros and signed a four-and-a-half-year contract.

[10] On 29 January 2020, Arana joined Atlético Mineiro on an 18-month loan deal, which included an obligatory purchase clause.

On 14 November 2020, Arana received his first call-up to the full national team ahead of a 2022 World Cup qualifier against Uruguay; he was picked as an emergency replacement for Alex Telles, who had withdrawn from the squad after being diagnosed with COVID-19.