Guillaume-Hippolyte Van Volxem (13 February 1791 – 17 April 1868) was a Belgian lawyer, liberal politician and mayor of the City of Brussels.

He began his political career in 1830, when he was designated as temporary member of the National Congress.

On 16 April 1843, the Catholic Jules d'Anethan became Minister for Justice after the Belgian elections in the spring of that year.

In 1845, at 54 years of age, Guillaume van Volxem withdrew from political life.

Married to Adélaïde Willems, then to Félicité Marischal (daughter of the very wealthy lawyer Jacques-Herman Marischal, administrator of the department of the Dyle, and aunt of Félix Paul Tiberghien [fr] and Arthur Warocqué [fr][1]), he was the father of Jules Van Volxem [fr].