[1] Latendresse was selected by the Drummondville Voltigeurs second overall in the 2003 Quebec Major Junior Hockey League (QMJHL) Entry Draft, just after Sidney Crosby, who was taken first overall by the Rimouski Océanic.

On November 7, 2006, during his first game on the Canadiens' top line, Latendresse tapped in a rebound past goaltender Dwayne Roloson to record his first career NHL goal against the Edmonton Oilers, 1:04 into the third period.

Just a few weeks earlier, Roy had said he thinks the only reason 19-year-old rookie Latendresse remained with the Canadiens is that he is a francophone, suggesting if his surname was "Smith" or "Brown," he would have been back in the QMJHL.

"[citation needed] Midway through his fourth season in Montreal, Latendresse was traded to the Minnesota Wild on November 23, 2009, for forward Benoît Pouliot.

[citation needed] On October 7, 2010, Latendresse scored the first goal of the 2010–11 season, just 3:33 into the first period, on Carolina Hurricanes goaltender Cam Ward in Helsinki, Finland.

[5] Latendresse's 2010–11 season was plagued with injuries; he required surgery to repair a sports hernia and a torn labrum in his hip, and he ultimately was forced to miss all but 11 games.

Latendresse and the other players had originally intended to be at the marathon's finish line during the time at which bombs exploded, killing three and injuring several spectators and runners.

[10] After an unsuccessful try-out with the Phoenix Coyotes, Latendresse signed a European contract with the ZSC Lions of the National League A in Switzerland.