[1] The original line to Guimarães was built to 1,000 mm (3 ft 3+3⁄8 in) gauge, and until 1932 passengers for Porto had to change trains onto the Linha do Minho at Trofa.

[7] The old and new station buildings are adjacent to each other, between the railway platforms and the Avenida Dom João IV, and are in the freguesia or civil parish of Urgezes.

In the middle of the 19th century, the Minho region suffered from a lack of communication with the rest of Portugal, due to its poor railway infrastructure.

This improved after the Portuguese Regeneration led by Fontes Pereira de Melo, when many railway lines were created, including those from Porto to Braga and Guimarães.

[1] On 16 September 1895, the Railway Gazette reported that contracts had been awarded to start construction on an avenue between Toural Square and Guimarães Station.

[13] By around 7 pm,the inaugural train arrived at Guimarães station, where a reception was held for president of the Portuguese republic, Óscar Carmona.

[17] In August 2007, a passenger was electrocuted, as well as two fireman that tried to rescue him; they were transported to the Senhora da Oliveira Hospital where they all made a full recovery.