U.S. policy seeks to encourage Guinea's democratic reforms, its positive contribution to regional stability, and sustainable economic and social development.

[2] However, the U.S. State Department instantly condemned the September 5, 2021 coup d'etat, and warned that "violence and any extra-constitutional measures... could limit the ability of the United States and Guinea’s other international partners to support the country..." The U.S. called for "national dialogue" to find a peaceful and sustainable way "forward.

USAID Guinea is now one of only five sustainable development missions in West Africa, with current core program areas in primary education, family health, democracy and governance, and natural resources management.

After a temporary suspension due to nationwide political unrest in early 2007, the Peace Corps program in Guinea resumed operations at the end of July.

Volunteers work in four project areas: secondary education, environment/agro-forestry, public health and HIV/AIDS prevention, and small enterprise development.