Guissona (Catalan pronunciation: [giˈsona]) is a town and municipality located in the north of the comarca (county) of Segarra, in the Province of Lleida, Catalonia, Spain.

The economy of Guissona is based on farming (plant crops, animal husbandry) and the food processing industry.

A table with the total population registered in Guissona in different years since 1497: The first settlement known is the Iberian town of Iesso dating back to the early Iron Age (8th-9th century BC).

The archeological site includes the water supply of the actual Medieval enclosure, the wells of the public fountain, a number of headstones (e.g., the gravestone of Servilla Praepusa (2nd-3rd century AD), a sculpture of a Roman horseman, and the necropolis located in the area of Cal Mines.

Guissona probably housed the episcopal see until it was moved to La Seu d'Urgell as a consequence of the Muslim invasion of the area.

The final work would be a mixture of different phases of Baroque (altars, organ, choir stalls) and Neoclassical styles.

The Carlist army commanded by the Infante Sebastian of Portugal and Spain was defeated by the Baron of Meer, general-in-chief of the military region of Catalonia.