The Gulf of Darién (UK: /ˈdɛəriən, ˈdær-/, US: /ˌdɛəriˈɛn, ˌdɑːr-, dɑːrˈjɛn/, Spanish: [daˈɾjen]) is the southernmost region of the Caribbean Sea, located north and east of the border between Panama and Colombia.

Within the gulf is the Gulf of Urabá, a small lip of sea extending southward, between Caribana Point and Cape Tiburón, Colombia, on the southern shores of which is the port city of Turbo, Colombia.

[2][3][4][5][1] The Gulf of Darién was the site of the Darien scheme, autonomous Scotland's one major attempt at colonialism.

The first expedition of five ships (Saint Andrew, Caledonia, Unicorn, Dolphin, and Endeavour) set sail from Leith on July 14, 1698, with around 1,200 people on board.

[7] After calling at Madeira and the West Indies, the fleet made landfall off the coast of Darien on November 2.